fig15

Figure 15. Example of the application of copper chalcogenide nanoparticles in animal immunotherapy. (A) Schematic of anti-tumor immune responses induced by CuS-PEG-Mal-based PTT plus immune checkpoint inhibitors^[153]; (B) Illustration of gradually synthesized CuS-RNP@PEI; and (C) Copper-based NIR photo-triggered synergetic photothermal cancer immunotherapy vectors and PTPN2 targeted immunotherapy^[188]; (D) Schematic diagram of preparation and synthesis of AM@DLMSN@CuS/R848; (E) AM@DLMSN@CuS/R848 has a synergistic therapeutic effect on triple-negative breast cancer TNBC by combining photothermal ablation and immune remodeling^[149]. (A): Copyright © American Chemical Society 2019; (B)-(C): Copyright © Elsevier Ltd. 2021; (D)-(E): Copyright © American Chemical Society 2020. PEI: polyethyleneimine; PTT: photothermal therapy.